Integrin alphaVbeta3

An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).

Also Known As:

Integrin alpha-v beta-3; Receptors, alpha-v beta-3 Integrin; Vitronectin Receptor; alpha-v beta-3 Integrin Receptors; Integrin alpha v beta 3; Receptor, Vitronectin; Receptors, alpha v beta 3 Integrin; alpha v beta 3 Integrin Receptors; alpha-v beta-3, Integrin; alphaVbeta3, Integrin; beta-3, Integrin alpha-v

Carbohydrates: 22516
- Glycoconjugates: 1370
  - Glycoproteins: 25180
    - Membrane Glycoproteins: 2277
      - Platelet Membrane Glycoproteins: 1215
        Integrin alphaVbeta3: 582
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Glycoproteins: 25180
    - Membrane Glycoproteins: 2277
      - Platelet Membrane Glycoproteins: 1215
        Integrin alphaVbeta3: 582
  - Membrane Proteins: 10262
    - Membrane Glycoproteins: 2277
      - Platelet Membrane Glycoproteins: 1215
        Integrin alphaVbeta3: 582
    - Cell Surface Receptors: 2156
      - Immunologic Receptors: 10
        Integrins: 14566
        Cytoadhesin Receptors
        Vitronectin Receptors: 9
        Integrin alphaVbeta3: 582
        Platelet Membrane Glycoproteins: 1215
        Integrin alphaVbeta3: 582

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A N Chubukina Research Topics

Disease

Drug/Important Bio-Agent (IBA)